Detox-N-Cleanse is a 100% vegan Food supplement. Detox-N-Cleanse is
a synergistic blend of foods and food extracts intended to help support
healthy colon, urinary, metal, and other detoxification.
Pollution can be a serious issue [1], so many naturally-minded
individuals are justifiably concerned about detoxification.
The
outside air is polluted, the indoor air is polluted, water is polluted,
and the industrialized food supply is polluted with toxins. There
are vehicle exhausts, industrial gases, industrial chemicals,
chlorinated-fluoridated-plasticized tap water, molds, pesticides,
herbicides, preservatives, radiation, colorings, perfumes, colognes,
medications, printer/copier dusts, paints, carpet out-gassing, cleaning
supplies, and a host of other pollutants. Even toys are still
found containing toxic chemicals (and even those that have supposedly
“safe” materials, like plastic, can still outgas).
Detoxification from toxins makes a great deal of sense in this chemically-altered modern world.
“The
etiology of many neurodegenerative diseases has been only partly
attributed to acquired traits, suggesting environmental factors may
also contribute. Metal dyshomeostasis causes or has been implicated in
many neurodegenerative diseases” [2]. Some believe that heavy
metals also predispose people to candidiasis/systemic mycoses and/or
intestinal issues [3-4].
Acerola Cherry is one of the most vitamin C dense Foods [5].
Not only does it have free radical scavenging abilities, it also has
been shown to increase the antioxidant abilities of some other foods
[6]. “Acerola…contains bioflavonoids” [6],
anthocynins, and quercitin [7]. One study concluded that vitamin
C “supplementation provides a protective effect against
exercise-induced airway narrowing in asthmatic subjects” [8].
Vitamin C has been used to help detoxify from aluminum, arsenic,
cadmium, lead, mercury, nickel, and more [9]. Acerola cherries
also contain soluble and insoluble fiber, and such fibers are often
part of successful colon cleanses.
Apple Pectin
has been shown to support and improve colon health [10-13], and it also
provides fiber [13]. Apple pectin exerts “a scavenger effect in
the intestinal digestion and portal circulation system as an
anti-inflammatory food” [13]. Apple pectin has been successfully
given as a radioprotection agent to reduce radiation levels in those
affected by Chernobyl [14-15]. It has long been used for those
with dyspepsia and other digestive complaints [9].
Bioflavonoids are found in acerola cherry, cilantro, collinsonia, garlic, wheat grass, and other plants. Bioflavonoids, such as Quercitin dihydrate
have long been used for toxicities. Even the PDR admits that
quercitin may “have benefit in some allergic conditions, in conditions
characterized by capillary fragility, in chronic prostates and in some
cancers…Quercetin is one of several flavonoids that have effects on
mast cells and basophils…it might be useful in some allergies, such as
hay fever. Quercetin can help prevent the release of histamine
and other mediators of allergies, possibly stabilize cell membranes so
that they are less reactive to allergens” [5]. “The major active
biological constituents in Citrus herbs are flavonoids, especially
hesperidin, naringin and alkaloids, mainly synephrine, with beneficial
medical effects on human health” [17]. Quercetin is often advised
for those with asthma, allergic rhinitis, or hay fever [18].
Bioflavonoids are also sometimes simply called flavonoids. Citrus
bioflavonoids have been found to have anti-allergic effects and may be
useful to improve symptoms associated with seasonal allergic rhinitis
[19].
Chlorella is a
special type of algae. Chlorella is often used for heavy metal
and other forms of detoxification. It has the ability to absorb
mercury, cadmium, arsenic and other heavy metals [9]. The PDR
states, “Chlorella…contains chlorophyll, car otenoids, such as
astaxanthin, canthaxanthin, flavoxanthin, loraxanthin, neoxanthin, and
violaxanthin. Chlorella also contains the xantho phyll,
echinenone…Chlorella has putative anticarinogenic, immunomodulatory,
hypolipidemic, gastric mucosal-protective and detoxification
activities…In rats, chlorella was found to promote the excretion of
dioxin…Chlorella had demonstrated ability to protect against
gamma-radiation, as well as a number of drugs and various toxic
chemicals” [5]. Live chlorella has been found to remove lead from
waste water [23].
Chlorophyll is
contained in chlorella, cilantro, and wheat grass. Chlorophyll
has been used to help detoxify from fluoride and as well as toxic
substances [5,9]. It “may ameliorate some drug side effects”
[5]. Chlorophyll is often a component of successful colon detox
programs.
Cilantro Coriandrum sativum is
also known as Chinese parsley. It has been found to accelerate
the excretion of lead and mercury through urine [24]. It has also
been found to remove both inorganic and methyl forms of mercury
[25]. Another study concluded that cilantro “has suppressive
activity on lead deposition, probably resulting from the chelation of
lead by some substances contained in Chinese parsley” [26].
Collinsonia Root is
also called stone root and has tonic effects, which may be due to its
essential oil and rosmaric acid [16]. It contains a relatively
unique bioflavonoid 2,5-dihydroxy-dimethoxyflavone, along with the
flavones “baicalein-6,7-dimethyl ether (2), norwogenin-7,8-dimethyl
ether (3), and tectochrysin (5-hydroxy-7-methoxyflavone)” [27]. It is
most often used for stomach complaints, hemorrhoids, or constipation
[28,29], while its tonic effects within the bowels help maintain a
state of calm (and also helps the bowels function more
naturally). It is “[o]f reputed value in Varicose Vein conditions
and for Hemorrhoids” [30]. It has long been used in combination
with ox bile to help support bile flow and deal with indigestion
[31]. Collinsonia root “is used for calculi, kidney stones, urea
(bladder semolina), bladder inflammation, dropsy and gastrointestinal
disorders” [32].
Garlic has been used to help detoxify from aluminum, arsenic, beryllium, lead, mercury, and nickel [9]. “Garlic is
used internally as an adjuvant to
dietetic measures for elevated lipid
levels. The herb is also used for prevention of age-related
vascular changes and arteriosclerosis”. “Garlic
contains compounds that help prevent
nitrites—common substances found in foods as
well as a variety of every day pollutants—from transforming themselves
into nitrosamines, harmful compounds that
can trigger cancerous changes in the body” [8]. Garlic has
anti-oxidant effects which means
it can reduce toxicity associated
free-radical damage. “Garlic contains the
trace elements germanium and selenium,
which have been thought to play a role in improving host
immunity and ‘normalizing’ the oxygen utilization in
neoplastic cells” [18]. Garlic compounds have been found to
inhibit lipid peroxidation, which “is considered to be one of the main
features of aging in liver cells” [18].
Methionine
is an essential amino acid and a precursor to l-cysteine [5].
“L-methionine may protect against the toxic effects of hepatoxins, such
as acetaminophen” and “methotrexate” [5]. Methionine is a
powerful antioxidant…which inactivates free radicals…As levels of toxic
substances in the body increases, the need for methionine increases”
[18]. Much of the methionine in the body is converted into
S-adenosylmethlonine, which is an active agent for many enzymatic
reactions. Various methionine-containing compounds have been used to
help detoxify from aluminum, arsenic, cadmium, ethanol, lead,
molybdenum, mercury, nickel, and thimerosal [9,33]. A study
involving chickens revealed that the odor, hence contents, of fecal
matter is influenced by methionine supplementation [34]. It has
been speculated that people with diseases such as Alzheimer’s and
Parkinson’s would benefit from methionine-containing compounds [35].
Modified Citrus Pectin
(from inner citrus peel) is one of the most effective known natural
detoxifiers. It has been found to be effective for many heavy
metals [36]. A urinary output study found that it can reduce
toxic metals like lead and cadmium in people with supposed “normal”
levels of those toxins [37]. Additionally, has reduced lead in
children with toxic lead levels [38]. It has been claimed that,
“Even though modified citrus pectin is strong enough to soak up toxins
and heavy metals in your system like a sponge, it is also gentle on
your system. Not a single person in these human trials reported
any side effects. Modified citrus pectin is one of the safer
forms of toxin removal because it does NOT deplete essential minerals
your body needs. So while it eliminates toxic metals and
pesticides like lead, cadmium, and mercury, it doesn’t deplete your
body of zinc, calcium, or magnesium” [39]. Pectin has been used
to help detoxify from mercury and nickel [9]. “Heavy metals like
mercury, lead, cadmium and arsenic have been implicated in a wide
number of health problems, including arteriosclerosis, hypertension,
multiple sclerosis, impaired immune function, and an overgrowth of
Candida albicans. Research exists showing the effectiveness of pectin
in chelating (binding to) heavy metals and removing them from the body”
[3]. It has been studied for prostate issues “for further
chemopreventive and chemotherapeutic analysis in vivo”[40]. Detox-N-Cleanse contains
PectaSol® (which is a registered trademark of EcoNugenics, Inc.) as
this particular version of modified citrus pectin has been perhaps the
most extensively tested for efficacy in detoxification.
N-Acetyl-L-Cysteine
(NAC) is the delivery form of l-cysteine [5], which is an amino
acid. It is a reducing agent that has proven antioxidant activity
for scavenging free radicals [5]. “Cysteine helps detoxify
harmful toxins and protect the body from radiation damage. It is
one of the best free radical destroyers. N-acetylcysteine aids in
preventing side effects from chemotherapy and radiation therapy” [18].
NAC is sometimes used “for boosting intracellular glutathione
levels” [41] and it more effective than even glutathione itself to do
that [18]. At high doses, it has been found to be an antidote for
acetaminophen poisoning and Amanita phalloides
intoxification” [5]. Various cysteine-containing compounds have
been used to help detoxify from aluminum, arsenic, cadmium, lead,
mercury, and nickel [9,42,43]. NAC seems to be able to reduce
nitrates and serum levels of the medication carbamazepine [5].
NAC has “antioxidant properties and chelating ability” and a rat study
found it had protective effects against lead toxicity for the kidneys
[42]. According to one study, “N-acetylcysteine prevents memory
deficits, the decrease in acetylcholinesterase activity and oxidative
stress in rats exposed to cadmium” [44].
Slippery Elm
is an herb long used for successful colon cleansing. “The main
focus of Slippery Elm is the GI Tract where it can provide nutrition, a
soothing coat over stomach and intestinal ulcers, soothing the
colon…and to absorb foul gases [45]. “Slippery elm contains large
amounts of mucilage, which will coat the surface of the mucous
membranes or surface of wounds and sores when it comes in contact with
water…Slippery elm has been successfully used as a demulcent and
emollient” [16]. “It has also been known to ‘draw out’ toxins,
boils, splinters, and other irritants” [46]. Historically, it has been
used “in the treatment of gastritis and gastric or duodenal ulcers”
[16]. Some believe slippery elm is “effective for
protection against stomach ulcers, colitis, diverticulitis, gut
inflammation, and acidity. Slippery elm is also useful for
diarrhea, constipation, hemorrhoids, irritable bowel syndrome, and to
expel tapeworms” [46].
Wheat Grass Triticum aestivum is a highly akalizing Food
[47]. It has long been used to re-invigorate health, and for
other complaints of fatigue [48]. Wheat grass is rich in
chlorophyll [5]. Wheat grass has been used to help detoxify
from fluoride and as well as other toxic substances [5,9]. “Wheat
grass is used as a general health tonic and… a…beneficial role of wheat
grass in ameliorating hyperlipidemia and the associated oxidative
stress” [49]. It may help with certain types of IBS (irritable
bowel syndrome) [5,50].
CNN reported
about a small American study recently found 232 unnatural chemicals in
the umbilical cords of newborn human infants [51]. We are living
in an age where there are too many chemicals and other toxins in the
environment.
Detox-N-Cleanse contains
natural vitamin C from acerola cherries (and no isolated ascorbic
acid), herbs, and other plant extracts that support healthy
detoxification. It is the choice for natural health professionals
interested in 100% Food detoxification.
Detox-N-Cleanse Video
References
[1]
Tecer LH, Alagha O, Karaca F, Tuncel G, Eldes N. Particulate Matter
(PM(2.5), PM(10-2.5), and PM(10)) and Children's Hospital Admissions
for Asthma and Respiratory Diseases: A Bidirectional Case-Crossover
Study. J Toxicol Environ Health A. 2008;71(8):512-20
[2] Yokel
RA. Blood-brain barrier flux of aluminum, manganese, iron and
other metals suspected to contribute to metal-induced
neurodegeneration. J Alzheimers Dis. 2006 Nov;10(2-3):223-53
[3] Fuchs N. The amazing health benefits of modified citrus
pectin. New Living Magazine, October 2003
[4] Thiel, R. Systemic mycoses: An overview for natural health
professionals. The Original Internist, 14:2, June 2007:57-66
[5] Sheldon SH, Rorvik D, eds. PDR for Nutritional
Supplements. Medical Economics, Montvale (NJ), 2001
[6] Hwang J, Hodis HN, Sevanian A. Soy and alfalfa phytoestrogen
extracts become potent low-density lipoprotein antioxidants in the
presence of acerola cherry extract. J Agric Food Chem.
2001;49(1):308-314
[7] Hanamura T, Mayama C, Aoki H, Hirayama Y, Shimizu M.
Antihyperglycemic effect of polyphenols from Acerola (Malpighia
emarginata DC.) fruit. Biosci Biotechnol Biochem. 2006
Aug;70(8):1813-20
[8] Tecklenburg SL, Mickleborough TD, Fly AD, Bai Y, Stager JM.
Ascorbic acid supplementation attenuates exercise-induced
bronchoconstriction in patients with asthma. Respir Med. 2007
Aug;101(8):1770-8
[9] Thiel R. Serious Nutrition for Health Care Professionals, 3rd
ed. Center for Natural Health Research, Arroyo Grande (CA),
1997
[10] Shinohara K, Ohashi Y, Kawasumi K, Terada A, Fujisawa T. Effect of
apple intake on fecal microbiota and metabolites in humans. Anaerobe.
2010 Mar 19. [Epub ahead of print]
[11] Licht TR, Hansen M, Bergström A, Poulsen M, Krath BN, Markowski J,
Dragsted LO, Wilcks A. Effects of apples and specific apple
components on the cecal environment of conventional rats: role of apple
pectin. BMC Microbiol. 2010 Jan 20;10:13
[12] Liu L, Li Y, Niu Y, Sun Y, Guo Z, Li Q, Li C, Feng J, Cao S, Mei
Q. An Apple Oligogalactan Prevents against Inflammation and
Carcinogenesis by Targeting LPS/TLR4/NF-{kappa}B Pathway in A Mouse
Model of Colitis-Associated Colon Cancer. Carcinogenesis. 2010
Apr 16. [Epub ahead of print]
[13] Tazawa K, Yatuzuka K, Yatuzuka M, Koike J, Ohkami H, Saito T,
Ohnishi Y, Saito M. [Dietary fiber inhibits the incidence of
hepatic metastasis with the anti-oxidant activity and portal scavenging
functions] [Article in Japanese]. Hum Cell. 1999 Dec;12(4):189-96
[14] Nesterenko VB, Nesterenko AV. Decorporation of Chernobyl
radionuclides. Ann N Y Acad Sci. 2009 Nov;1181:303-10
[15] Bandazhevskaya GS, Nesterenko VB, Babenko VI, Yerkovich TV,
Bandazhevsky YI. Relationship between caesium (137Cs) load,
cardiovascular symptoms, and source of food in 'Chernobyl' children --
preliminary observations after intake of oral apple pectin. Swiss
Med Wkly. 2004 Dec 18;134(49-50):725-9
[16] Gruenwald J, Brendler T, Jaenicke C, editors. PDR for Herbal
Medicines, 4th ed. Thomson, Montvale (NJ), 2007
[17] Ding L, Luo X, Tang F, Yuan J, Liu Q, Yao S. Simultaneous
determination of flavonoid and alkaloid compounds in Citrus herbs by
high-performance liquid chromatography-photodiode array
detection-electrospray mass spectrometry. J Chromatogr B Analyt
Technol Biomed Life Sci. 2007 Oct 1;857(2):202-9
[18] Balch JF, Balch PA. Prescription for Nutritional
Healing. Avery Publishing, Garden City (NY), 1997
[19] Tanabe S, Kinuta Y, Yasumatsu H, Takayanagi M, Kobayashi S, Takido
N, Sugiyama M. Effects of Citrus unshiu Powder on the Cytokine Balance
in Peripheral Blood Mononuclear Cells of Patients with Seasonal
Allergic Rhinitis to Pollen. Biosci. Biotechnol. Biochem. 2207, 71
(11), 2852–2855
[20] Mohapatra DK, Mohanty L, Mohanty RC, Mohapatra PK. Biotoxicity of
mercury to Chlorella vulgaris as influenced by amino acids. Acta Biol
Hung. 1997;48(4):497-504
[21] Huckabee JW, Blaylock BG. Transfer of mercury and cadmium
from terrestrial to aquatic ecosystems. Adv Exp Med Biol. 1973;40:125-60
[22] Levy JL, Stauber JL, Adams MS, Maher WA, Kirby JK, Jolley
DF. Toxicity, biotransformation, and mode of action of arsenic in
two freshwater microalgae (Chlorella sp. and Monoraphidium arcuatum).
Environ Toxicol Chem. 2005 Oct;24(10):2630-9
[23] Kumar R, Goyal D. Comparative biosorption of Pb2+ by live algal
consortium and immobilized dead biomass from aqueous solution.
Indian J Exp Biol. 2009 Aug;47(8):690-4
[24] Omura Y, Beckman SL. Role of mercury (Hg) in resistant
infections & effective treatment of Chlamydia trachomatis and
Herpes family viral infections (and potential treatment for cancer) by
removing localized Hg deposits with Chinese parsley and delivering
effective antibiotics using various drug uptake enhancement
methods. Acupunct Electrother Res. 1995 Aug-Dec;20(3-4):195-229
[25] Karunasagar D, Krishna MV, Rao SV, Arunachalam J. Removal
and preconcentration of inorganic and methyl mercury from aqueous media
using a sorbent prepared from the plant Coriandrum sativum. J
Hazard Mater. 2005 Feb 14;118(1-3):133-9
[26] Aga M, Iwaki K, Ueda Y, Ushio S, Masaki N, Fukuda S, Kimoto T,
Ikeda M, Kurimoto M. Preventive effect of Coriandrum sativum
(Chinese parsley) on localized lead deposition in ICR mice. J
Ethnopharmacol. 2001 Oct;77(2-3):203-8
[27] Stevens JF, Ivancic M, Deinzer ML, Wollenweber E. A novel
2-hydroxyflavanone from collinsonia Canadensis. J Nat Prod. 1999
Feb;62(2):392-4
[28] Cotran RS, Kumar V, Collins T. Robbins Pathologoical Basis
for Disease, 6th ed. WB Saunders, Phil, 1999
[29] Scalzo R. Naturopathic Handbook of Herbal Formulas, 3rd
ed. Kivaki Press, Durango (CO), 1994
[30] Lee R. Collinsonia. In Product Bulletins, circa 1950
[31] Lee R. Cholacol. In Product Bulletins, circa 1950
[32] Gruenwald J, Brendler T, Jaenicke C, eds. PDR for Herbal
Medicine, 2nd ed. Medical Economics, Montvale (NJ), 2000
[33] Waly M, Olteanu H, Banerjee R, Choi SW, Mason JB, Parker BS,
Sukumar S, Shim S, Sharma A, Benzecry JM, Power-Charnitsky VA, Deth RC.
Activation of methionine synthase by insulin-like growth factor-1 and
dopamine: a target for neurodevelopmental toxins and thimerosal. Mol
Psychiatry. 2004 Apr;9(4):358-70
[34] Chavez C, Coufal CD, Carey JB, Lacey RE, Beier RC, Zahn JA. The
impact of supplemental dietary methionine sources on volatile compound
concentrations in broiler excreta. Poult Sci. 2004
Jun;83(6):901-10
[35] Newman PE. Alzheimer's disease revisited. Med Hypotheses. 2000 May;54(5):774-6
[36] Eliaz I, Weil E, Wilk B. Integrative medicine and the role of
modified citrus pectin/alginates in heavy metal chelation and
detoxification--five case reports. Forsch Komplementmed. 2007
Dec;14(6):358-64
[37] Eliaz I, Hotchkiss AT, Fishman ML, Rode D. The effect of
modified citrus pectin on urinary excretion of toxic elements.
Phytother Res. 2006 Oct;20(10):859-64
[38] Zhao ZY, Liang L, Fan X, Yu Z, Hotchkiss AT, Wilk BJ, Eliaz
I. The role of modified citrus pectin as an effective chelator of
lead in children hospitalized with toxic lead levels. Altern Ther
Health Med. 2008 Jul-Aug;14(4):34-8
[39] Sears A. 6-day citrus detox. Doctor’s House Call, June 28, 2010
[40] Yan J, Katz A. PectaSol-C modified citrus pectin induces apoptosis
and inhibition of proliferation in human and mouse androgen-dependent
and- independent prostate cancer cells. Integr Cancer Ther. 2010
Jun;9(2):197-203
[41] McCarty MF. Potential utility of full-spectrum antioxidant
therapy, citrulline, and dietary nitrate in the management of sickle
cell disease. Med Hypotheses. 2010 Jun;74(6):1055-8
[42] Wang L, Wang Z, Liu J. Protective effect of N-acetylcysteine
on experimental chronic lead nephrotoxicity in immature female
rats. Hum Exp Toxicol. 2010 Jul;29(7):581-91
[43] Trümpler S, Nowak S, Meermann B, Wiesmüller GA, Buscher W,
Sperling M, Karst U. Detoxification of mercury species--an in vitro
study with antidotes in human whole blood. Anal Bioanal Chem.
2009 Nov;395(6):1929-35
[44] Gonçalves JF, Fiorenza AM, Spanevello RM, Mazzanti CM, Bochi GV,
Antes FG, Stefanello N, Rubin MA, Dressler VL, Morsch VM, Schetinger
MR. N-acetylcysteine prevents memory deficits, the decrease in
acetylcholinesterase activity and oxidative stress in rats exposed to
cadmium. Chem Biol Interact. 2010 Jun 7;186(1):53-60
[45] Ritchason J. The Little Herb Encyclopedia, 3rd ed.
Woodland Health Books, Pleasant Grove (UT), 1995
[46] Burnham TH, et al, editors. The Review of Natural
Products. Facts and Comparisons, St. Louis. 2001
[47] Null G. The Complete Encyclopedia of Natural Healing. Kensington Books, NY, 1998
[48] Duke J.A. The Green Pharmacy. Rodale Press, Emmaus (PA), 1997
[49] Sethi J, Yadav M, Dahiya K, Sood S, Singh V, Bhattacharya
SB. Antioxidant effect of Triticum aestivium (wheat grass) in
high-fat diet-induced oxidative stress in rabbits. Methods Find
Exp Clin Pharmacol. 2010 May;32(4):233-5
[50] Langmead L, Rampton DS. Review article: complementary and
alternative therapies for inflammatory bowel disease. Aliment Pharmacol
Ther. 2006 Feb 1;23(3):341-9
[51] Gupta S. Toxic Childhood. CNN, August 7, 2010
Some
of these studies (or citations) may not conform to peer review
standards (though most do). Therefore, the results are not conclusive.
Professionals can, and often do, come to different conclusions when
reviewing scientific data. None of these statements have been reviewed by the FDA.
All products distributed by Doctors’ Research, Inc. are nutritional and
are not intended for the treatment or prevention of any medical
condition.