CoQ10-Cardio provides nutritional support for the heart, gums, and for overall circulation.  Current and historical references suggest that substances contained within the ingredients in CoQ10-Cardio can nutritionally help support the heart, increase endurance, aid with energy, aid with gum health, and promote better overall health. 

Since the cardiovascular system is too important to rely on a few incomplete isolated nutrients, CoQ10-Cardio is made up of the highest quality Foods to provide the nutrients that natural health professionals are looking for to support the cardiovascular system.  Although sometimes used by those with hypertension, it is also taken by athletes interested in better performance, individuals who want more energy, as well as some with hypotension.

CoQ10-Cardio contains the following Foods:

Acerola Cherry is one of the most vitamin C dense Foods.  Not only does it have free radical scavenging abilities, it also has been shown to increase the antioxidant abilities of some other foods [1].  “Vitamin C’s antioxidant effects are well established.  It has been reported to protect plasma lipids from oxidative damage…and appears to play an important role in its possible cardioprotective activity…Several studies have shown that vitamin C has positive effects on hypertension” [2].  Acerola cherries also naturally contain bioflavonoids which some may find helpful for gum (gingival) health.

CoEnzyme Q10 is very important to health. “Co-Q10 has antioxidant activity in mitochondria and cellular membranes, protecting against peroxidation of lipid membranes.  It also inhibits the oxidation of LDL-cholesterol.  LDL oxidation is believed to play a significant role in the pathogenesis of atherosclerosis…It takes about three weeks of daily dosing with CoQ10 to reach maximal serum concentrations.  Coenzyme Q10 may be indicated in cardiovascular disease, particularly in congestive heart failure…Significant CoQ10 deficiencies have been noted in diseased gingiva. CoQ10’s efficacy in reducing gingival inflammation and periodontal pocket-depth has been demonstrated in placebo-controlled trials…There is also some evidence that CoQ10 might boost energy and speed recovery of exercise-related muscle exhaustion and damage” [2].  “Also at the inner mitochondrial membrane level, coenzyme Q is recognized as an obligatory co-factor for the function of uncoupling proteins and a modulator of the transition pore. Furthermore, recent data reveal that CoQ10 affects expression of genes involved in human cell signalling, metabolism, and transport and some of the effects of exogenously administered CoQ10 may be due to this property. Coenzyme Q is the only lipid soluble antioxidant synthesized endogenously… In patients with stable moderate CHF, oral CoQ10 supplementation was shown to ameliorate cardiac contractility and endothelial dysfunction” [3].

As certain cholesterol-lowering medications can dangerously reduce serum CoQ10 [2,4], some medical doctors advise taking CoQ10 if those type of medications are also being taken [4-5].  A medical doctor has written, “Cholesterol is one type of body fat.  The enzyme in the liver that makes sugar into cholesterol turns up its activity when insulin levels rise.  Insulin levels rise following carbohydrate meals or excess mental stress (among other promoters)…Statin drugs work, in part, because they poison this liver enzyme’s ability to listen to the insulin message.  The trouble with poisons concerns their inevitable side effect and toxicities.  One of the nasty side effects from these medications concerns the depletion of Co enzyme Q10 in the body.  The heart needs the lion’s share of this important nutrient.  Deficiency here causes one type of heart failure” [5].

Research has suggested that “CoQ10 may be beneficial in Parkinson’s disease” [6].  “Coenzyme Q10 appears to slow the progressive deterioration of function in PD, but these results need to be confirmed in a larger study” [7].

CoQ10 has also been taken by people with asthma, cancer, epilepsy, neurological disorders, skin concerns, and many other disorders [6,8,9].  CoQ10 has been shown to reduce some of the negative symptoms associated with aging [8].

Interestingly, CoQ10 absorption is improved with Foods [10]. This may be because it is lipid soluble and is absorbed better when bile salts are released. 100% Food  CoQ10-Cardio has lipid-containing Foods that are expected to improve absorption, such as hawthorn and garlic [11].

Garlic constituents appear to have selective inhibition on platelet aggregation and adhesion, platelet functions that may help reduce the risk of myocardial infarction and ischemic stroke [12]. “Inhibition of thrombocyte aggregation, increased bleeding time and clotting time, and enhancement of fibrinolytic activity have been demonstrated in clinical trials” using garlic constituents [13].  Garlic has been found to lower LDL (but not HDL) and to slightly reduce blood pressure in those with high cholesterol [14].  Garlic intake has been found to reduce age-related increases in aortic stiffness [15].  Its antioxidant effects appear responsible for decreasing premature aging [13]; garlic “is also used for prevention of age-related vascular changes and arteriosclerosis”.  In addition to alliins [13], garlic naturally also contains benfotiamine, which is a natural form of vitamin B1 with its own health benefits.

Hawthorn Berry “[d]ilates the coronary blood vessels, lowers cholesterol levels, and restores heart muscles, [i]ncreases intracellular vitamin C levels”, and is [u]seful for anemia, cardiovascular and circulatory disorders, high cholesterol, and lowered immunity” [9].  “Because of its strong cardiac activity, hawthorn has been suggested to be of use in CHF {congestive heart failure} and cardiac performance…At least one report exists on the plant’s potential
antiarrhythmic effects…Hawthorn flavonoid components also possess vasodilatory action…Hawthorn  is  known  to
be beneficial in myocardial ischemia…Hawthorn has been studied for the prevention and treatment of atherosclerosis…{and} hypertension…Other effects of hawthorn include oxygen species scavenging activity…and the ability to treat elective mutism” [16].

Hawthorn contain bioflavonoids [17] and hence may possibly be beneficial for gum and/or capillary health [2,8,18].

Rice Bran is a natural source of B vitamins and fiber [13].

CoQ10-Cardio Video

REFERENCES

[1] Hwang J, Hodis HN, Sevanian A.  Soy and alfalfa phytoestrogen extracts become potent low-density lipoprotein antioxidants in the presence of acerola cherry extract.  J Agric Food Chem. 2001;49(1):308-314
[2] Sheldon S, Rorvik D, eds.  PDR for Nutritional Supplements.  Medical Economics, Montvale (NJ), 2001
[3] Littarru GP, Tiano L. Bioenergetic and antioxidant properties of coenzyme Q10: recent developments.  Mol Biotechnol. 2007 Sep;37(1):31-7
[4] Whitaker J.  What you don’t know about statin drugs can hurt you.  Health & Healing, 2005;15(5):3-6
[5] Ferril W.  Inflammation and heart disease, a holistic perspective.  Townsend Letter, 2005;262:54-56
[6] Werbach M.  Textbook of Medical Physiology.  Third Line Press, Tarzana (CA), 1999:604-615
[7] Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M; Parkinson Study Group. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct;59(10):1541-50
[8] Hamilton K. Clinical Pearls ISYS. ITServices, Sacramento, 2004
[9]  Balch JF, Balch PA.  Prescription for Nutritional Healing, 2nd ed.  Avery Publishing Group, Garden City Park (NY), 1997
[10] Ochiai A, Itagaki S, Kurokawa T, Kobayashi M, Hirano T, Iseki K. Improvement in intestinal coenzyme q10 absorption by food intake.  Yakugaku Zasshi. 2007 Aug;127(8):1251-4
[11] Pederson M.  Nutritional Herbology.  Whitman Books, Warsaw (IN), 1998
[12] Steiner M, Li W. Aged Garlic Extract, a Modulator of Cardiovascular Risk Factors: A Dose-Finding Study on the Effects of AGE on Platelet Functions.  J Nutr. 2001;131:980S-984S
[13] Gruenwald J, et al.  PDR for Herbal Medicines, 2nd ed.  Medical Economics, Montvale (NJ), 2000 
[14] Cholesterol, Blood Pressure and Garlic.  Nutr Week. 1997;27(20):7
[15] Mansoor  GA. Herbs and Alternative Therapies in the Hypertension Clinic.  Am J Hyperten. 2001;14:971-975
[16]  DerMarderosian A, ed.  The Review of Natural Products.  Facts and Comparisons, St. Louis 2000
[17] Peschel W, Bohr C, Plescher A.  Variability of total flavonoids in Crataegus - Factor evaluation for the monitored production of industrial starting material.. Fitoterapia. 2007 Jul 4
[18] Kovach AG, Buki B, Foldi M. The effects of the Crataegus extract esbericard on the fragility of blood capillaries.  Med Monatsschr. 1958 Nov;12(11):747-9

Some of these studies (or citations) may not conform to peer review standards. Therefore, the results are not conclusive. Professionals can, and often do, come to different conclusions when reviewing scientific data. None of these statements have been reviewed by the FDA. All products distributed by Doctors’ Research, Inc. are nutritional and are not intended for the treatment or prevention of any medical condition.